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KMID : 0390020100200020114
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Pediatric Allergy and Respiratory Disease
2010 Volume.20 No. 2 p.114 ~ p.121
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Clinical Aspects of Pneumonia with Tachypnea in Pediatric Patients with Influenza H1N1
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Choi Bo-Geum
Lee Dong-Won
Kim Yeo-Hyang
Hyun Myung-Chul
Lee Hee-Jung
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Abstract
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Background:We evaluated the clinical/laboratory characteristics and progress of pediatric patients hospitalized for pneumonia and laboratory-confirmed H1N1 influenza infection.
Methods:A total of 101 patients were enrolled. They were divided into 2 groups: group 1 with a fast respiration rate for age (n=66) and group 2 with an appropriate respiration rate for age (n=35). We retrospectively reviewed the medical charts to collect data on the hospitalized patients.
Results:Patients were significantly older in group 1 than in group 2 (median age, 7 vs. 4 years, P<0.001) and 59.0% were between 6 and 8 years of age. Sixteen patients (24.2%) in group 1 had underlying medical conditions, most of whom had asthma, and 50 were previously healthy. Oxygen saturation on admission day was significantly lower in group 1 than in group 2 (92% vs. 98%, P<0.001) and 42 patients (63.6%) in group 1 had hypoxia (oxygen saturation ? 92%). The frequency of lymphopenia was significantly higher in group 1 than in group 2 (n=59 vs. 11, P<0.001). Some patients in group 1 received systemic corticosteroid therapy, intravenous immunoglobulin infusion and oxygen supplement (n=28, n=16, n=48, respectively). The frequency of systemic corticosteroid therapy and oxygen supplement was higher in group 1 than in group 2 (P<0.001 for each).
Conclusions:H1N1 influenza infection complicated by pneumonia can cause severe illness in previously healthy children more than 6 years old and in children with uncontrolled allergic disease. Multi-center studies are needed to evaluate the clinical and epidemiologic characteristics of pediatric patients with 2009 H1N1 influenza.
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KEYWORD
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Child, Influenza, Pneumonia
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